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KMID : 0606320020180010089
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Journal of Phamacetical Sciences Sookmyung Women s University
2002 Volume.18 No. 1 p.89 ~ p.92
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Functional Importance of TRAF6-Binding Motifin IL-1 Mediated Signal Ttansduction
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Yim Mi-Jung
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Abstract
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Crystal structure of TRAF6 in complex with TRAF6-binding sites from CD4O was previously determined. The structure revealed a distinct TRAF6-binding groove of CD4O, the key ,itructural determinant of interaction. The structural information leads to a proposed TRAF6-binding motif. This allows the identification of TRAF6-binding sequences in the MRAK protein, whose functional require ment in IL- 1 mediated signal transduction is further demonstrated using site-directed mutagenesis. The mutational effects of hIRAk on the down-stream NF-kB signaling shows the importance of the TRAF6 interface for signaling by IL-1.
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